Author: Alpha Male

Alpha Male Plus Sex Health Inventory Total Score

Alpha Male Plus & Sexual Health Inventory for Men

These results from a clinical study published by the International Society for Sexual Medicine demonstrate that the combination of citrulline and resveratrol are effective at reducing symptoms of ED. In this study, 20 patients ages 29-78 were given these ingredients found in Alpha Male Plus (or placebo) for 4 weeks and then followed up with a standard sexual health questionnaire, the Sexual Health Inventory for Men. Citrulline and resveratrol improved erection firmness, erection confidence, intercourse satisfaction and total score. The SHIM score questionnaire has been shown to be simple, reliable, and valid for the assessment of erectile function in clinical trials [1], [2].

In pre-clinical experiments, citrulline improved intracavernous pressure and arterial pressure (ICP/MAP), smooth muscle/collagen ratios, and serum levels of NOx in patients with vascular-related ED and low-testosterone ED [3].Although few experiments have been performed on humans, one recent clinical study showed that oral L-citrulline supplementation improves the Erection Hardness Score (EHS) without adverse events in men with mild ED [4].

Previous studies have shown that resveratrol treatment leads to SIRT1 activation, and subsequently increased NOx leads to enhancement of cGMP synthesis via the NO/cGMP pathway that is responsible for maintaining an erection [5]. Resveratrol also causes an increase in firmness of the corpus cavernosum and an increase in blood testosterone levels [6].

Excitingly, this new clinical study combines those earlier insights and shows that citrulline and resveratrol have a synergistic effect on helping to improve erectile function and overall intercourse satisfaction.

Data adapted from Shirai M, Hiramatsu I, Aoki Y, et al. Sex Med 2018; 6:291-296.


  1. J. P. Mulhall, I. Goldstein, A. G. Bushmakin, J. C. Cappelleri, and K. Hvidsten, “Validation of the erection hardness score,” J. Sex. Med., vol. 4, no. 6, pp. 1626–1634, Nov. 2007.
  2. J. C. Cappelleri and R. C. Rosen, “The Sexual Health Inventory for Men (SHIM): A 5-year review of research and clinical experience,” International Journal of Impotence Research, vol. 17, no. 4. Nature Publishing Group, pp. 307–319, 05-Jul-2005.
  3. A. Shiota, Y. Hotta, T. Kataoka, M. Morita, Y. Maeda, and K. Kimura, “Oral l-Citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction,” J. Sex. Med., vol. 10, no. 10, pp. 2423–2429, Oct. 2013.
  4. L. Cormio et al., “Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction,” Urology, 2011.
  5. S. Fukuhara et al., “Vardenafil and Resveratrol Synergistically Enhance the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in Corpus Cavernosal Smooth Muscle Cells and Its Therapeutic Potential for Erectile Dysfunction in the Streptozotocin-Induced Diabetic Rat: Preliminary Findings,” J. Sex. Med., vol. 8, no. 4, pp. 1061–1071, Apr. 2011.
  6. S. Shin et al., “trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo,” Arch. Pharm. Res., vol. 31, no. 1, pp. 83–87, Jan. 2008.
natural citrulline source


When Citrulline is consumed in combination with Arginine, the body is prevented from breaking down Arginine too quickly. As a result, this special amino acid synergizes with Arginine to increase nitric oxide (NOx) levels to more sustained levels allowing for longer duration of sexual performance. Clinical trials show that Citrulline supplementation improves erection hardness in men with mild ED. Moreover, Citrulline also increased the frequency of sexual intercourse per month by almost 20%.


M. Shirai et al., “Oral L-citrulline and Transresveratrol Supplementation Improves Erectile Function in Men With Phosphodiesterase 5 Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study,” Sex. Med., 2018.

L. Cormio et al., “Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction,” Urology, 2011.

Arginine + Citrulline (1:1 Ratio)

AMP contains the magic 1:1 ratio that has been shown to synergistically improve vascular flow and erectile response. Moreover, clinical research has revealed that patients with erectile dysfunction have lower levels of both Arginine and Citrulline.


M. Morita et al., “Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability,” Biochem. Biophys. Res. Commun., 2014.     

A. Barassi et al., “Levels of L-arginine and L-citrulline in patients with erectile dysfunction of different etiology,” Andrology, 2017.



Using Resveratrol in combination with Citrulline improves erectile function even in men taking PDE-5 inhibitors, as demonstrated in a recent clinical trial. Thus, Alpha Male Plus is designed to benefit all men, including those who already utilize PDE-5 inhibitors yet are nonetheless seeking more power in the bedroom. Alpha Male Plus is the only men’s sexual health supplement that contains the correct ratio of Resveratrol and Citrulline to leverage these exciting clinical insights. 


M. Shirai et al., “Oral L-citrulline and Transresveratrol Supplementation Improves Erectile Function in Men With Phosphodiesterase 5 Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study,” Sex. Med., 2018.

vasodilation pump

Glycine Propionyl-L-Carnitine (GPLC)

For some men, one of the contributing factors to failure to maintain a satisfactory erection is diabetes or pre-diabetes (ie. insulin resistance) that is increasingly common in middle-aged med. Fortunately, GPLC is a powerful vasodilation amino acid that can increase blood flow, and it has been shown to benefit erectile strength specifically in men with blood sugar control issues. 

Similar to Resveratrol, GPLC has been studied clinically for its ability to improve erectile function in men currently taking PDE-5 inhibitors. After 24 weeks of treatment of GPLC supplementation on top of existing PDE-5i usage, there were marked improvements in the ability to achieve and maintain erections, with 68% of patients experiencing improved erectile function compared to using PDE-5 inhibitors alone.

Also, GPLC enhances anaerobic work capacity (with reduced lactate production) in men, which permits longer sessions in the bedroom before exhaustion.


V. Gentile, P. Vicini, G. Prigiotti, A. Koverech, and F. Di Silverio, “Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes,” Curr. Med. Res. Opin., 2004.

Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ: Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009, 6: 9-10.

Bloomer, R. J., Smith, W. A., & Fisher-Wellman, K. H. (2007). Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men. Journal of the International Society of Sports Nutrition4, 22.

Muira Puama

Muira Puama

This exotic plant sourced from our partners in the Amazon rainforest basin is rich in natural alkaloids and flavonoids, and it has demonstrated rigorous clinical efficacy in improving both libido and erectile function. 


R. Shamloul, “Natural aphrodisiacs,” Journal of Sexual Medicine, vol. 7, no. 1 PART 1. Blackwell Publishing Ltd, pp. 39–49, Jan-2010.

S. Nguyen, J. Rajfer, and M. Shaheen, “Safety and efficacy of daily Revactin® in men with erectile dysfunction: A 3-month pilot study,” Transl. Androl. Urol., 2018.

A. J. Bella and R. Shamloul, “Traditional plant aphrodisiacs and male sexual dysfunction,” Phytotherapy Research. 2014.

S. A. Pratap and S. Rajender, “Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities,” Front. Biosci. – Sch., 2012.


Methylfolate (L-5-MTHF)

This potent molecule is the primary bioactive form of folate which is utilized by your body at the cellular level. It is also the form found in blood circulation which can be transported across cell membranes into tissues. Methylfolate rapidly improves endothelial function by increasing nitric oxide bioavailability.

By comparison, regular folic acid (vitamin B9) must undergo a slow enzymatic alteration in order to become bioactive, thus delaying peak onset. Only Methylfolate achieves peak plasma concentration rapidly, working to maximize blood vessel expansion where you need it most.


C. Antoniades et al., “5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling,” Circulation, 2006.

R. Van Etten, E. De Koning, M. Verhaar, C. Gaillard, and T. Rabelink, “Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate,” Diabetologia, 2002.

Pyrroloquinoline Quinone (PQQ)

PQQ is a newly appreciated & powerful plant-based antioxidant derived from kiwi fruit that improves reproductive performance and promotes vasodilation, as demonstrated in preclinical trials multiple preclinical trials.


B. Q. Zhu et al., “Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury,” J. Cardiovasc. Pharmacol. Ther., 2006.

F. Steinberg et al., “Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets,” Exp. Biol. Med., 2003.

B. Zhang et al., “Transcriptome analysis of the effect of pyrroloquinoline quinone disodium (PQQ·Na2) on reproductive performance in sows during gestation and lactation,” J. Anim. Sci. Biotechnol., 2019.

B. Zhang et al., “Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny,” Br. J. Nutr., 2019.

Organic blueberry juice

Organic Blueberry Juice

Blueberries are the foundational ingredient of AMP and they are packed with dietary flavonoids and anthocyanins, both which are associated with improved sexual health.


A. Cassidy, M. Franz, and E. B. Rimm, “Dietary flavonoid intake and incidence of erectile dysfunction,” Am. J. Clin. Nutr., 2016.

I. Mykoniatis et al., “Dietary flavonoid intake and erectile dysfunction among young men of reproductive age,” Clin. Nutr. ESPEN, 2018.

Organic Agave Nectar

Organic Agave Nectar

This subtly sweet nectar is sustainably extracted from Agave plants in the American Southwest. It possesses a low glycemic index (GI) so it doesn’t spike your blood sugar like corn syrup or other low value sweeteners. Agave nectar also has a greater phytochemical potential than other sweeteners due to the presence of more natural compounds with antioxidant activity.


I. O. Velázquez Ríos et al., “Phytochemical profiles and classification of Agave syrups using 1H-NMR and chemometrics,” Food Sci. Nutr., 2019.

  • 1
  • 2
Alpha Male Logo Icon

© All rights reserved.

Alpha Male Plus

3280 E. Hemisphere Loop Suite 190
Tucson, Arizona 85706

Follow Us